Mark en zijn vrienden hebben zomervakantie van de universiteit. Maar superhelden kunnen niet zomaar op vakantie. Mark wordt geconfronteerd met de gevolgen van Omni-Mans dubbelleven.
Gastrollen:
Fred Tatasciore(Adam / Driver / Killcannon (voice)), Grey Griffin(Betsy / Polly (voice)), Andrew Rannells(William (voice)), Chris Diamantopoulos(Rodgers / Green Ghost / Dad (voice)), Walton Goggins(Cecil (voice)), Zazie Beetz(Amber (voice)), Gillian Jacobs(Eve (voice)), Jason Mantzoukas(Rex / Zombie #2 (voice)), Zachary Quinto(Robot / Dinosaur #1 / Zombie #4 (voice)), Malese Jow(Dupli-Kate / Zombie #3 (voice)), Khary Payton(Black Samson / Officer / Doctor (voice)), Zehra Fazal(Louise / Astronaut #2 (voice)), Reginald VelJohnson(Principal/Dean Winslow (voice)), Gary Anthony Williams(Space Director / TV Announcer / Graduation Announcer (voice)), Ross Marquand(Immortal / Aquarus / Tech (voice)), Tatiana Maslany(Queen Lizard (voice)), Sterling K. Brown(Angstrom Levy (voice)), Jay Pharoah(Bulletproof / Dinosaur #2 / Zombie #1 (voice)), Nyima Funk(Additional Voices (voice)), Robert Kesselman(Additional Voices (voice)), Dan Navarro(Additional Voices (voice)), Ami Shukla(Additional Voices (voice)), Micah Aliling(Louise's Daughter (voice)), Cleveland Berto(Darkwing / Husband / Royal Guard #1 (voice)), Cliff Curtis(Paul (voice)), Scoot McNairy(King Lizard (voice)), Ben Schwartz(Shapesmith / Rus / Tech Trooper #2 (voice)), Kari Wahlgren(Female Thraxan / GDA Agent / Announcer (voice))
